摘要
采用紫外活化二氧化氯自由基(ClO2·)氧化甲基的方法,在聚乳酸(PLA)表面接枝了羧基等含氧官能团,以增加PLA表面的亲水性和生物相容性。通过X射线光电子能谱分析和接触角分析,探究了改性后PLA表面元素组成的变化、最佳的氧化条件及氧化反应对PLA表面亲水性的影响。通过拉伸实验分析了氧化过程对PLA力学性能的影响。通过体外细胞增殖和细胞活性测试研究了改性后PLA表面的生物相容性变化。结果表明,羧基等含氧官能团在PLA表面成功生成;最佳氧化时间为10 min,最佳氧化温度为90℃,该条件下氧化后材料的表面接触角由82°降低至62.5°,表面亲水性得到改善;改性后PLA的拉伸强度不变,断裂伸长率略有下降;氧化后PLA表面显示出更好的细胞黏附能力和细胞增殖能力,更有利于细胞的生长。
The oxygen-containing functional groups such as carboxyl groups were generated on the surface of poly(lactic acid)(PLA)by means of methyl oxidation through ultraviolet-activated sodium chlorite free radicals(ClO·).This can enhanced the hydrophilicity and cytocompatibility of the PLA surface.The surface element composition,optimum oxida-tion condition,and influence of oxidation reaction on the surface hydrophilicity of PLA were investigated by X-ray photo-electron spectroscopy and contact angle analysis.The effect of oxidation process on the mechanical properties of PLA was analyzed through a tensile test.The biocompatibility of the surface-modified PLA was studied by cell proliferation and cell activity tests in vitro.The experimental results indicated that the oxygen-containing functional groups such as car-boxyl group were successfully generated on the surface of PLA.The optimal oxidation time and temperature were deter-mined to be 10 min and 90℃,respectively.Under such a condition,the surface contact angle of the oxidized material de-creased from 82°to 62.5°,but its surface hydrophilicity was improved.The surface-modified PLA exhibited the un-changed tensile strength and a slight decrease in elongation at break.After oxidation,the surface of PLA showed better cell adhesion and cell proliferation,which was more beneficial to the growth of cells.
出处
《中国塑料》
CAS
CSCD
北大核心
2021年第5期17-23,共7页
CHINA PLASTICS
基金
国际科技合作项目(2015DFA30550)
河南省高等学校重点科技项目(19A430003)
福建工程学院开放基金项目(KF-C19009)。
