摘要 食物过敏已成为全球性的健康问题。花生是最常见的食物过敏原之一,即使微量的暴露也可导致严重过敏反应。绝大多数的花生过敏可持续终身。目前对花生过敏患者的管理是严格的过敏原回避和意外暴露后的及时治疗。口服免疫治疗(oral immunotherapy,OIT)通过调节免疫系统可诱导发生过敏反应阈值的提高。近年来临床医生开始探索花生OIT来保护花生过敏患者发生严重甚至危及生命的过敏反应。本文将从花生OIT的机制、疗效、安全性及对生活质量的影响等方面进行阐述。 Food allergy is a global problem.Peanut is one of the most common food allergens that can result in anaphylaxis,even with milligram exposure.Most peanut allergies could persist lifelong.The current standard of care for peanut allergy is strict dietary avoidance and immediate treatment of allergic reaction triggered by accident exposure.Oral immunotherapy(OIT)induces an increased reactivity threshold via modulation of the immune system.In recent years,peanut OIT has been developed to protect peanut-allergic individuals against severe or life-threating allergic reaction.This review discussed the update of the mechanism,efficacy,safety and impact on quality of life of peanut OIT for peanut allergy.
机构地区 武汉大学中南医院过敏反应科
出处 《中华预防医学杂志》 CAS CSCD 北大核心 2021年第5期592-597,共6页 Chinese Journal of Preventive Medicine
分类号 R59 [医药卫生—内科学]
