摘要 目的探讨地方性氟中毒地区不同孕期妊娠妇女氟摄入量与血清碱性磷酸酶(ALP)的相关性。方法2020年4月收集长期居住于山东省济宁市任城区、金乡县、嘉祥县,菏泽市郓城县地方性氟中毒病区妊娠期妇女资料,根据妊娠妇女孕周,分为早孕组(0~12周)、中孕组(13~27周)以及晚孕组(>27周),检测各组妊娠妇女尿氟、血清ALP及骨代谢指标[包括骨钙素(BGP)、β-Ⅰ型胶原C端肽(β-CTX)、Ⅰ型胶原N端前肽(PINP)]水平,采用相关性检验分析不同孕期妊娠妇女尿氟与ALP、骨代谢指标的相关性。结果共纳入妊娠期妇女372人,早孕组97例、中孕组169、晚孕组106例。3组妊娠妇女尿氟水平比较差异无统计学意义[(1.20±0.25)、(1.23±0.19)、(1.24±0.30)mg/L,P>0.05]。3组妊娠妇女血清ALP水平比较差异有统计学意义(P<0.05),其中早孕组妊娠妇女ALP水平显著低于中孕组及晚孕组(P均<0.05),中孕组妊娠妇女ALP水平显著低于晚孕组(P<0.05)。3组妊娠妇女血清β-CTX水平比较差异无统计学意义(P>0.05);3组血清BGP、PINP水平比较差异均有统计学意义(P均<0.05),其中晚孕组妊娠妇女血清BGP、PINP水平均显著高于早孕组与中孕组(P均<0.05),早孕组与中孕组妊娠妇女血清BGP、PINP水平比较差异均无统计学意义(P均<0.05)。早孕组妊娠妇女尿氟水平与ALP呈正相关(r=0.364,P<0.05),与骨代谢指标BGP、β-CTX、PINP均未见相关性(r=0.164、0.117、0.136,P均>0.05);中孕组妊娠妇女尿氟水平与ALP呈正相关(r=0.417,P<0.05),与骨代谢指标BGP、β-CTX、PINP均未见相关性(r=0.127、0.108、0.129,P均>0.05);晚孕组妊娠妇女尿氟水平与ALP及骨代谢指标均未见相关性(r=0.179、0.158、0.184、0.149,P均>0.05)。结论地方性氟中毒地区妊娠期妇女尿氟水平在妊娠期间较为平稳;早孕期及中孕期阶段,尿氟水平影响妊娠妇女ALP分泌。提示在地方性氟中毒地区仍需加强改水降氟措施,以减少过量� Objective To explore the correlation between fluoride intake and serum alkaline phosphatase(ALP)in pregnant women of different gestational periods in endemic fluorosis area.Methods Pregnant women in Rencheng District,Jinxiang County,Jiaxiang County of Jining City and Yuncheng County of Heze City were selected in April 2020.According to the gestational weeks,pregnant women were divided into early pregnancy group(0-12 weeks),middle pregnancy group(13-27 weeks)and late pregnancy group(>27 weeks).The levels of urinary fluoride,ALP,osteocalcin(BGP),C-terminal peptide ofβ-Ⅰcollagen(β-CTX)and N-terminal propeptide of typeⅠcollagen(PINP)of pregnant women in each group were measured,and the correlation between urinary fluoride and ALP,BGP,β-CTX,and PINP in pregnant women of different gestational periods was analyzed.Results A total of 372 pregnant women were selected,including 97 cases in early pregnancy group,169 cases in middle pregnancy group and 106 cases in late pregnancy group.There was no significant difference in urinary fluoride level between the three groups[(1.20±0.25),(1.23±0.19),(1.24±0.30)mg/L,P>0.05].There was significant difference in serum ALP among the three groups(P<0.05),among them,the ALP level in early pregnancy was significantly lower than those of middle pregnancy group and late pregnancy group(P<0.05),and the ALP level in middle pregnancy was significantly lower than that of late pregnancy group(P<0.05).There was no significant differences in serumβ-CTX among the three groups(P>0.05).There were significant differences in serum BGP and PINP levels among the three groups(P<0.05).The serum BGP and PINP levels in late pregnancy group were significantly higher than those of early pregnancy group and middle pregnancy group(P<0.05),and there were no significant differences in serum BGP and PINP levels between early pregnancy group and middle pregnancy group(P<0.05).There was a significant positive correlation between urinary fluoride and ALP in early pregnancy group(r=0.364,P<0.05),but no sign
出处 《中华地方病学杂志》 CAS 北大核心 2021年第5期399-403,共5页 Chinese Journal of Endemiology
分类号 R71 [医药卫生—妇产科学]
