摘要 目的:观察麝香保心丸辅助常规西药治疗急性心肌梗死(AMI)气滞血瘀证的临床疗效。方法:选取AMI患者95例,按随机数字表法分为麝香保心丸组50例与常规组45例。常规组给予常规西药治疗,麝香保心丸组在常规组治疗方案的基础上加用麝香保心丸治疗。治疗8周后,比较2组临床疗效、症状改善情况,并检测心功能[左心室射血分数(LVEF)、左心室收缩末期容积(LVESV)、左心室舒张末期容积(LVEDV)]、血管内皮功能[一氧化氮(NO)、内皮素(ET)]。结果:临床总有效率麝香保心丸组96.00%,高于常规组75.56%,差异有统计学意义(P<0.05)。治疗后,2组中医证候积分较治疗前下降(P<0.05),且麝香保心丸组低于常规组(P<0.05)。治疗后,2组LVEF水平较治疗前上升,LVESV、LVEDV水平较治疗前下降(P<0.05),麝香保心丸组LVEF水平高于常规组,LVESV、LVEDV水平低于常规组(P<0.05)。治疗后,2组血清NO水平较治疗前上升,血清ET水平较治疗前下降(P<0.05),麝香保心丸组血清NO水平高于常规组,血清ET水平低于常规组(P<0.05)。结论:麝香保心丸辅助常规西药治疗AMI气滞血瘀证疗效确切,可有效帮助患者减轻临床症状,使其心功能、血管内皮功能明显改善。 Objective:To observe the clinical effect of Shexiang Baoxin pills assisting routine western medicine for acute myocardial infarction(AMI) with qi stagnation and blood stasis syndrome. Methods:A total of 95 cases of AMI patients were selected and divided into the Shexiang Baoxin pills group and the routine group according to the random number table method,50 and 45 cases in each group respectively. The routine group was treated with routine western medicine,and the Shexiang Baoxin pills group was additionally treated with Shexiang Baoxin pills based on the treatment of the routine group.After eight-week treatment,the clinical effect and the improvement of symptoms in the two groups were compared;the heart function including left ventricular ejection fraction(LVEF),left ventricular end-systolic volume(LVESV) and left ventricular end-diastolic volume(LVEDV) as well as the vascular endothelial function including nitric oxide(NO) and endothelin(ET) in the two groups were detected. Results:The total clinical effective rate was 96.00% in the Shexiang Baoxin pills group,higher than that of 75.56% in the routine group, the difference being significant(P<0.05). After treatment, Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment(P<0.05),and the score in the Shexiang Baoxin pills group was lower than that in the routine group(P<0.05). After treatment,LVEF levels in the two groups were increased when compared with those before treatment,and levels of LVESV and LVEDV were decreased(P<0.05);LVEF level in the Shexiang Baoxin pills group was higher than that in the routine group, and levels of LVESV and LVEDV were lower(P<0.05). After treatment,NO levels in serum in the two groups were increased when compared with those before treatment,and ET levels in serum were decreased(P<0.05);NO level in the Shexiang Baoxin pills group was higher than that in the routine group,and ET level was lower(P<0.05). Conclusion:Shexiang Baoxin pills assisting routine western medicine for AMI w
机构地区 台州市立医院心血管内科
出处 《新中医》 CAS 2021年第6期34-37,共4页 Journal of New Chinese Medicine
关键词 急性心肌梗死 气滞血瘀证 麝香保心丸 左心室射血分数 左心室收缩末期容积 左心室舒张末期容积 一氧化氮 内皮素 Acute myocardial infarction Qi stagnation and blood stasis syndrome Shexiang Baoxin pills Left ventricular ejection fraction Left ventricular end-systolic volume Left ventricular end-diastolic volume Nitric oxide Endothelin
