大型真菌来源鸟巢烷型二萜研究进展

摘要鸟巢烷型二萜是大型真菌来源二萜化合物中最大的类群,其化学结构特征是包含5/6/7元环杂合的三环骨架。由于鸟巢烷型二萜具有以刺激神经生长因子合成为代表的多种生物活性,其人工合成和相关药物开发引起了广泛关注。总结近年来报道的来源于黑蛋巢菌属(Cyathus)、猴头菌属(Hericium)和肉齿菌属(Sarcodon)等大型真菌的多种鸟巢烷型二萜的化学结构和生物活性,介绍其化学合成和生物合成方面的研究进展。 Cyathanes with 5/6/7 ring-fused diterpenes are the largest group of diterpenoids from macrofungi.Due to their rich biological activities,especially the nerve growth factor-inducing activity,cyathanes have attracted considerable attentions in terms of drug discovery and compound synthesis.This review compiled research progress on chemical structure and biological activity of cyathanes from Cyathus,Hericium and Sarcodon.Progress on both chemical synthesis and biosynthesis of cyathanes were also reviewed so as to provide a reference for research and development of natural products from macrofungi in the future.

作者彭勤颖邹根高利慧白林泉 TAN Yeeshin 吴莹莹 PENG Qinying;ZOU Gen;GAO Lihui;BAI Linquan;TAN Yeeshin;WU Yingying(Institute of Edible Fungi,Shanghai Academy of Agricultural Sciences,National Engineering Research Center of Edible Fungi,Key Laboratory of Applied Mycological Resources and Utilization(South),Ministry of Agriculture and Rural Affairs,P.R.China,Shanghai 201403,China;State Key Laboratory of Microbial metabolism,School of Life Sciences&Biotechnology,Shanghai Jiao Tong University,Shanghai 200240,China;Institute of Biological Sciences,Faculty of Science&Mushroom Research Centre,University Malaya,Kuala Lumpur 50603,Malaysia)

机构地区上海市农业科学院食用菌研究所上海交通大学生命科学技术学院马来亚大学生物科学研究所

出处《食用菌学报》 CSCD 北大核心 2021年第2期140-154,共15页 Acta Edulis Fungi

基金上海市闵行区“领军人才”培养计划(201947) 上海市科委国际科技合作基金项目(18390741000)。

关键词鸟巢菌化学结构生物活性化学合成生物合成二萜环化酶 Bird’s nest fungi chemical structure biological activity chemical synthesis biosynthesis diterpene cyclase

分类号 G63 [文化科学—教育学]