摘要 梅毒是由梅毒螺旋体(Treponema pallidum)亚种苍白螺旋菌引起的性传播感染性疾病,主要通过母婴感染或性接触的方式传播。梅毒螺旋体的外膜蛋白在梅毒螺旋体的传播和宿主的黏附等方面起重要作用,因此,鉴定可以作为抗生素作用靶点的梅毒螺旋体外膜蛋白一直是梅毒疫苗开发的研究重点。本文重点阐述了梅毒螺旋体外膜蛋白的结构功能等特性,并将目前针对细菌外膜蛋白为靶点的药物的研究进展进行总结,以期为针对梅毒螺旋体的外膜蛋白为靶点的相关药物的研发提供一些新思路。 Syphilis,an infectious disease caused by Treponema pallidum subspecies pallidum,is mainly transmitted through mother-to-child infection or sexual contact.The outer membrane proteins of T.pallidum play important roles in the transmission and the adhesion to the hosts.Therefore,the identification of outer membrane proteins from T.pallidum,which can be used as the target of antibiotics,has become the research focus of vaccine development for syphilis.This review focuses on the structural and functional research of the outer membrane proteins of T.pallidum,and also summarizes the current research progresses on the development of drugs that target bacterial outer membrane proteins,in order to provide an overview and perspective aiming at the development of new drugs against T.pallidum.
出处 《微生物学报》 CAS CSCD 北大核心 2021年第3期539-554,共16页 Acta Microbiologica Sinica
基金 国家自然科学基金(31770901) 中国医学科学院医学与健康科技创新工程(2017-I2M-1-012) 北京协和医学院“中央高校基本科研业务费”(3332019065)。
