摘要 本文使用堆砌硅珠法以硅溶胶为原料、苏氨酸(L-Thr)为手性源构造手性环境,制备具有手性分离能力的全无机介孔手性硅胶球,对其进行元素分析、红外光谱法分析、透射电镜、扫描电镜和氮气吸附等表征,采用HPLC法探究无机介孔硅胶球制备的固定相对手性异构体和苯系位置异构体的拆分性能,成功分离了9对外消旋化合物和8种苯系位置异构体。L-Thr手性硅胶球在手性分离方面具有一定的可行性,并且在位置异构体的分离上具有良好的分离性能,色谱的重复性良好。 Using the stacking silica beads method,silica sol as the raw material,and threonine(L-Thr)as the chiral source to construct a chiral environment,we prepared the inorganic mesoporous chiral silica balls stationary phase with chiral separation capabilities.Elemental analysis,infrared spectroscopy,transmission electron microscope,scanning electron microscopy,and nitrogen adsorption were used to characterize its structures.The separation of chiral isomers and benzene-based positional isomers on the stationary phase was carried out through high-performance liquid chromatography(HPLC).Nine racemic compounds and eight benzene position isomers were successfully separated.The L-Thr chiral molecularly imprinted silica gel stationary phase has certain feasibility in chiral separation and good separation performance in the separation of positional isomers,and its chromatographic repeatability is good.
机构地区 云南师范大学化学化工学院
出处 《化学通报》 CAS CSCD 北大核心 2021年第3期267-272,193,共7页 Chemistry
基金 国家自然科学基金项目(21675141)资助。
关键词 手性异构体 苯系位置异构体 无机介孔硅胶球 HPLC 手性分离 Chiral isomer Benzene position isomer Inorganic mesoporous silica ball HPLC Chiral separation
分类号 O62 [理学—有机化学]
