EFNA5基因生理功能的研究进展

摘要肝配蛋白A5(Ephrin A5,EFNA5)是受体酪氨酸激酶家族(RTKs)成员之一,定位于细胞膜,在皮肤、脑、脾、肾脏、心脏和脂肪中均有较高表达。EFNA5能够与其受体结合发挥重要的生理功能,如参与神经发生、血管生成、促进细胞增殖与分化、平衡葡萄糖稳态、维持晶状体发育、调控雌性哺乳动物生殖、动员脂肪产热等。本文对EFNA5基因的定位、结构特征、生理功能、在癌症及畜牧等方面的研究现状进行综述,以期为EFNA5的进一步探究提供参考。 Ephrin A5(EFNA5)is a member of the(RTKs)family of receptor tyrosine kinases.It is located in the cell membrane and is highly expressed in skin,brain,spleen,kidney,heart and fat.EFNA5 can bind to its receptors and play important physiological functions,such as participating in neurogenesis,angiogenesis,promoting cell proliferation and differentiation,balancing glucose homeostasis,maintaining lens development,regulating the reproduction of female mammals,mobilizing fat to produce heat,and so on.In this paper,the location,structural characteristics,physiological function,cancer and animal husbandry research progress of EFNA5 gene were reviewed,in order to provide reference for the further exploration of EFNA5.

作者薛佳佳曹阳高一吴健李旭肖成张国梁 XUE Jiajia;CAO Yang;GAO Yi;WU Jian;LI Xu;XIAO Cheng;ZHANG Guoliang(College of Animal Science and Technology,Jilin Agricultural University,Jilin Changchun 130000 China;Animal Husbandry Division,Jilin Academy of Agricultural Sciences,Jilin Gongzhuling 136100 China;Jilin Kuncheng Animal Husbandry Technology Development Co.,Ltd.,Jilin Gongzhuling 136100 China;Key Laboratory of Beef Cattle Genetics and Breeding,Ministry of Agriculture and Rural Affairs,Jilin Gongzhuling 136100,China;Jilin Province Beef Cattle Breeding and Breeding Technology Innovation Center,Jilin Gongzhuling 136100,China)

机构地区吉林农业大学动物科学技术学院吉林省农业科学院吉林坤成牧业科技发展有限公司农业农村部肉牛遗传育种重点实验室吉林省肉牛繁育及养殖技术科技创新中心

出处《中国畜牧杂志》 CAS 北大核心 2021年第4期55-60,共6页 Chinese Journal of Animal Science

基金国家重点研发计划项目(2018YFD0501802) 国家现代农业产业技术体系专项(CARS-37) 吉林省科技发展计划项目(20180412020XH) 吉林省农业科技创新工程项目(C92072027) 家养动物种质资源平台。

关键词 EFNA5 基因定位结构特征生理功能癌症研究进展 EFNA5 Gene localization Structural characteristics physiological functions Cancer Advancement

分类号 S813 [农业科学—畜牧学]