摘要 目的探讨盐酸吗啡缓释片和盐酸羟考酮缓释片治疗肝功能异常患者癌性疼痛(癌痛)的疗效及安全性。方法选取2013年6月至2018年6月该院收住的伴有肝功能受损的癌痛患者52例为研究对象,分为A组(27例)和B组(25例)。A组采用口服盐酸吗啡缓释片治疗,B组采用口服盐酸羟考酮缓释片治疗。比较两组患者治疗后疼痛缓解情况、联合用药情况、肝功能状况、主要不良反应发生情况。结果治疗1 h后B组疼痛缓解率高于A组,治疗24 h后低于A组(P<0.05),治疗72 h后、1周后两组差异无统计学意义(P>0.05)。A、B组分别有9例(33.3%)、10例(40.0%)患者联用其他止痛药物,差异无统计学意义(P>0.05)。治疗前两组患者肝功能状况、主要不良反应发生率无差异(P>0.05),治疗后B组肝功能2级、便秘、恶心呕吐、眩晕发生率高于A组(P<0.05)。结论盐酸羟考酮缓释片超短期内快速镇痛效果较优,对肝功能不良影响较大;盐酸吗啡缓释片镇痛持久性更优,对轻中度肝功能受损者安全性较好。 Objective To investigate the efficacy and safety of morphine hydrochloride sustained release tablet and oxycodone hydrochloride sustained release tablet for treating cancer pain in the patients with liver dysfunction.Methods Fifty-two patients with cancer pain complicating liver function injury in this hospital from June 2013 to June 2018 were selected as the study subjects and divided into the group A(27 cases)and B(25 cases).The group A orally took the morphine hydrochloride sustained release tablet,while the group B adopted oral oxycodone hydrochloride sustained release tablet.The pain relief,combined medication,liver function and major adverse reactions occurrence after treatment were compared between the two groups.Results The pain relief rate at 1 h after treatment in the group B was higher than that in the group A(P<0.05),which at 24 h after treatment was lower than that in the group A(P<0.05),and the difference at 72 h and 1 week after treatment between the two groups had no statistical significance(P>0.05).The combination with other analgesic drugs were observed in 9 cases(33.3%)in the group A and 10 cases(40.0%)in the group B,and the difference was not statistically significant(P>0.05).The liver finction status and incidence rate of main adverse reactions before treatment had no statistical difference between the two groups(P>0.05).The incidence rates of liver function grade 2,constipation,nausea and vomiting and vertigo in the group B were higher than those in the group A(P<0.05).Conclusion Oxycodone hydrochloride sustained release tablet has good effect in ultrashort term rapid analgesia and great influence on the liver function damage;morphine hydrochloride sustained release tablet is better in long lasting analgesia,and has good safety for the patients with moderate liver function damage.
机构地区 柳州市人民医院肿瘤科
出处 《重庆医学》 CAS 2021年第7期1174-1177,共4页 Chongqing medicine
关键词 肝功能受损 癌性疼痛 盐酸吗啡缓释片 盐酸羟考酮缓释片 治疗结果 药物不良反应 impaired liver function cancerous pain morphine hydrochloride sustained-release tablet oxycodone hydrochloride sustained-release tablet treatment outcome adverse drug reaction
分类号 R730.5 [医药卫生—肿瘤]
