非小细胞肺癌患者临床疗效及预后的影响因素

摘要目的研究非小细胞肺癌(NSCLC)的临床疗效及相关预后因素。方法2013年6月-2020年6月,于复旦大学附属华东医院呼吸科治疗的155例NSCLC患者,分为手术组(n=47)和非手术组(n=108)。比较2组的临床特征,随访观察患者的中位总生存时间(OS)、中位无进展生存(PFS)及生存率,分析影响NSCLC预后的相关因素。结果155例患者年龄44~88岁,平均(64.2±7.8)岁,其中男性92例、女性63例。截至2020年6月30日,非手术组生存率为8.33%(9/108),中位OS为16.2个月(95%CI:14.3~18.1),中位PFS为7.6个月(95%CI:5.9~9.3);手术组生存率为25.53%(12/47),中位OS为24.2个月(95%CI:18.0~30.4),中位PFS为18.9个月(95%CI:10.5~27.3)。2组在吸烟人数、男性吸烟人数、TNM分期、治疗方案、疗效、生存状态方面的差异有统计学意义。单因素分析显示,吸烟(X²=14.349,P<0.001)和病理分型(X²=21.147,P<0.001)与非手术组NSCLC患者的预后相关,且男性吸烟(X²2=6.587,P=0.010)和女性吸烟(X²=5.155,P=0.023)均与NSCLC的预后相关。而性别、年龄、吸烟、体力状况评分、病理分型、T分期、淋巴结转移数、远处转移、骨转移和脑转移均与手术组NSCLC患者的预后无关(均P>0.05)。多因素分析提示,吸烟(HR=2.265,95%CI:1.469-3.491,P<0.001)是非手术组NSCLC患者预后的独立危险因素。结论接受-线手术治疗的NSCLC患者预后可能更好,吸烟是影响非手术组NSCLC患者生存的独立危险因素。 Objective To study the clinical therapeutic efficacy and prognostic factors in patients with non-small cell lung cancer(NSCLC).Msthods 155 patients with NSCLC treated in the Respiratory Department of Huadong Hospital Affiliated to Fudan University from June 2013 to June 2020 were divided into the operation group(n=47)and non operation group(n=108).The clinical characteristics,median overall survival(OS),median progression free survival(PFS),and survival rate were compared between the two groups and the related factors affecting the prognosis of patients were analyzed.Results 155 patients were 44 to 88 years old,with an average of(64.2±7.8)years old,of which 92 were males and 63 were females.As of June 30,2020,the survival rate of non-surgical group was 8.33%(9/108),the median OS was 16.2 months(95%CT:14.3-18.1),the median PFS was 7.6 months(95%CI:5.9-9.3).The survival rate of surgical group was 25.53%(12/47),the median OS was 24.2 months(95%CT:18.0-30.4),the median PFS was 18.9 months(95%CT:10.5-27.3).There were significant differences in the number of smokers,the number of male smokers,TNM stage,treatment plan,curative effect and survival status between the two groups.Univariate analysis showed that smoking(X²=14.349,P<0.001),pathological type(X²=21.147,P<0.001)were associated with the prognosis of NSCLC patients in the non-operation group,and smoking in men(X²=6.587,P=0.010)and women((X²=5.155,P=0.023)were all associated with the prognosis of NSCLC patients.However gender,age,smoking,physical status score,pathological type,TNM stage,number of lymph node metastasis,distant metastasis,bone metastasis and brain metastasis were not associated with the prognosis of NSCLC patients in the operation group(P>0.05).Multivariate analysis showed that smoking(HR=2.265,95%CI:1.469-3.491,(P<0.001)were the risk prognostic factors for NSCLC patients in the non operation group.Conclusion The prognosis of NSCLC patients receiving first-line surgery may be better,and smoking is an independent risk factor affecting the

作者唐中豪林开李向阳裴晓黎阿布都卡地尔·阿布都拉买尔旦江·艾尔肯 Tang Zhonghao;Lin Kai;Li Xiangyang;Pei Xiaoli;Abudukadier·Abudula;Maierdanjiang·Aierken(Department of Pulmonary and Critical Care Medicine,Huadong Hospital Affiliated to Fudan University,Shanghai,200040;Department of General Practice,Kashgar Prefecture Second People's Hospital,Kashi,Xinjiang,844000;Department of General Practice,Ningbo Medical Center Lihuili Hospital,Ningbo,Zhejiang Province,315000,P.R.China)

机构地区复旦大学附属华东医院呼吸与危重症医学科新疆维吾尔自治区喀什地区第二人民医院全科医学科宁波市医疗中心李惠利医院全科医学科

出处《老年医学与保健》 CAS 2021年第2期245-249,共5页 Geriatrics & Health Care

基金新疆维吾尔自治区自然科学基金项目(2020D01C087)。

关键词吸烟人数华东医院脑转移呼吸科总生存时间临床疗效 NSCLC 单因素分析 non-small cell lung cancer efficacy prognosis survival analysis

分类号 R73 [医药卫生—肿瘤]