摘要 目的探讨急性脑梗死后肺炎患者病原微生物变化及与IL-8、TNF-α、Bcl-2关系。方法选择2017-07—2019-07河南科技大学第一附属医院收治的126例急性脑梗死患者,根据是否合并肺炎分为合并组(n=57)与未合并组(n=69),比较2组血清IL-8、TNF-α、Bcl-2水平及肺部病原微生物检出情况,并分析其相关性。结果合并组革兰阴性菌(68.42%)、革兰阳性菌(45.61%)、真菌检出率(17.54%)显著高于未合并组(分别为2.90%、1.45%、1.45%);合并组IL-8(61.2±0.43)μg/L、TNF-α(4.19±0.58)μg/L,显著高于未合并组的(0.51±0.11)μg/L、(2.48±0.30)μg/L;Bcl-2(0.77±0.17)μg/L,显著低于未合并组的(1.52±0.35)μg/L;合并组肺部鲍曼不动杆菌、肺炎克雷伯杆菌、金黄色葡萄球菌、白假丝酵母菌与IL-8、TNF-α、Bcl-2水平显著相关。结论急性脑梗死后肺炎患者肺部病原微生物检出率随着血清IL-8、TNF-α水平上升及Bcl-2水平下降而增加,可为临床防治提供参考。 Objective To investigate the changes of pulmonary microecology and its correlation with interleukin-8(IL-8),tu⁃mor necrosis factor-α(TNF-α)and B cell leukemia-2(Bcl-2)in patients with pneumonia after acute cerebral infarction.Methods The clinical data of 126 patients with acute cerebral infarction admitted to our hospital from July 2017 to July 2019 were prospectively analyzed.Patients were divided into two groups according to the presence or absence of the pneumonia,pneumonia group(n=57)and non-pneumonia group(n=69).Serum IL-8,TNF-α,Bcl-2 levels and the detection rate of pulmonary pathogen⁃ic microorganisms were compared between groups.Spearman correlation was used to analyze the correlation between pulmonary patho⁃genic microorganisms and IL-8,TNF-α,Bcl-2 in patients with acute cerebral infarction complicated with pneumonia.Results The detection rates of Gram-negative bacteria(68.42%),Gram-positive bacteria(45.61%)and fungi(17.54%)in the pneumonia group were significantly higher than those in the non-pneumonia group(2.90%,1.45%,1.45%,respectively,P<0.05).Gram-negative bacteria were the most common pathogenic microorganisms in acute cerebral infarction patients complicated with pneumonia,followed by Gram-positive bacteria and fungi.The levels of serum IL-8(61.2±0.43)μg/L and TNF-α(4.19±0.58)μg/L in the pneumonia group were significantly higher than those in the non-pneumonia group((0.51±0.11)μg/L,(2.48±0.30)μg/L,P<0.05).The serum Bcl-2(0.77±0.17)μg/L level in the pneumonia group was significantly lower than that in the non-pneumonia group((1.52±0.35)μg/L,P<0.05).Pseudomonas aeruginosa,Escherichia coli,Enterobacter cloacae,Staphylococcus epidermidis,Streptococcus pneumoniae,Enterococcus,Candida tropicalis,Candida glabrata and IL-8 in patients with acute cerebral infarction complicated with pneumonia showed no correlation with TNF-αand Bcl-2(P>0.05).Acinetobacter baumannii,Klebsiella pneumoniae,Staphylococcus aureus and Candida albicans in patients with acute cerebral infarction complicated
机构地区 河南科技大学第一附属医院
出处 《中国实用神经疾病杂志》 2021年第4期289-294,共6页 Chinese Journal of Practical Nervous Diseases
基金 2018年度河南省医学科技攻关计划项目(编号:2018020277)。
关键词 急性脑梗死 肺炎 病原微生物 IL-8 TNF-Α BCL-2 血清 Acute cerebral infarction Pneumonia Pulmonary pathogenic microorganisms IL-8 TNF-α Bcl-2 Serum
