摘要 目的探讨糖尿病足术后感染危险因素及血清D-二聚体(D-D)、纤维蛋白原(FIB)、超敏C-反应蛋白(hs-CRP)的水平变化。方法选取2017年8月-2019年8月天津市南开区三潭医院综合外科收治的118例糖尿病足术后患者,根据术后是否发生感染分为感染组(n=57)和未感染组(n=61)。采用单因素及多因素Logistic回归分析影响糖尿病足术后感染的危险因素,同时对比两组术后1 d血清D-D、FIB、hs-CRP水平。结果术后1 d,感染组血清D-D、FIB、hs-CRP水平均高于未感染组,差异有统计学意义(P<0.05),溃疡数≥3个、术后血管并发症、术后骨髓炎的患者比例均高于未感染组(P<0.05);多因素Logistic回归分析结果显示,溃疡数≥3个、术后血管并发症、术后骨髓炎、D-D、FIB、hs-CRP水平偏高是糖尿病足术后感染的独立危险因素(P<0.05)。结论血清D-D、FIB、hs-CRP水平在糖尿病足术后感染患者中高表达,同时溃疡数≥3个、合并血管并发症、合并骨髓炎及D-D、FIB、hs-CRP水平偏高是糖尿病足术后感染的危险因素,临床应采取有效预防措施,降低感染发生率。 OBJECTIVE To explore the risk factors for postoperative infection in the diabetic foot patients and analyze the changes of levels of serum D-dimer(D-D),fibrinogen(FIB)and high-sensitivity C-reactive protein(hs-CRP).METHODS A total of 118 diabetic foot patients who underwent surgeries in general surgery department of Santan Hospital,Nankai District from Aug 2017 to Aug 2019 were enrolled in the study and divided into the infection group with 57 cases and the non-infection group with 61 cases according to the status of postoperative infection.Univariate analysis and multivariate logistic regression analysis were performed for the risk factors for postoperative infection in the diabetic foot patients.The levels of serum D-D,FIB and hs-CRP were observed and compared between the two groups after the surgery for 1 day.RESULTS The levels of serum D-D,FIB and hs-CRP of the infection group were significantly higher than those of the non-infection group after the surgery for 1 day(P<0.05).The proportions of the patients with no less than 3 ulcers,postoperative vascular complications and postoperative osteomyelitis were significantly higher in the infection group than in the non-infection group(P<0.05).The result of multivariate logistic regression analysis showed that the no less than 3 ulcers,postoperative vascular complications and postoperative osteomyelitis as well as high levels of D-D,FIB and hs-CRP were the independent risk factors for the postoperative infection in the diabetic foot patients(P<0.05).ConCLUSION The levels of serum D-D,FIB and hs-CRP are high in the diabetic foot patients with postoperative infection.The no less than 3 ulcers,vascular complications and osteomyelitis as well as high levels of D-D,FIB and hs-CRP are the risk factors for the postoperative infection in the diabetic foot patients.It is necessary for the hospital to take effective prevention measures so as to reduce the incidence of infection.
出处 《中华医院感染学杂志》 CAS CSCD 北大核心 2021年第6期862-865,共4页 Chinese Journal of Nosocomiology
基金 天津市自然科学基金资助项目(2019738)。
关键词 糖尿病足 细菌感染 危险因素 D-二聚体 纤维蛋白原 超敏C-反应蛋白 Diabetic foot Bacterial infection Risk factor D-dimer Fibrinogen High-sensitivity C-reactive protein
