摘要 目的综述MSCs在慢性创面治疗中的临床研究进展。方法广泛查阅近年来MSCs治疗慢性创面的相关文献,对MSCs治疗慢性创面的可能机制及其在临床慢性创面治疗中的应用情况、面临问题进行总结。结果 MSCs可参与到慢性创面愈合各个环节来促进创面愈合,在临床试验中展现出广阔应用前景。目前临床研究常用的MSCs包括骨髓来源MSCs、脂肪来源MSCs及脐带来源MSCs。结论 MSCs治疗慢性创面是一种具有前景的策略,但广泛应用于临床前还存在许多问题需进一步研究。 Objective To review the clinical research progress of mesenchymal stem cells(MSCs) in the treatment of chronic wounds. Methods The literature related to the chronic wound repair with MSCs at home and abroad in recent years was extensively reviewed, and the possible mechanism of MSCs in the treatment of chronic wounds,as well as its application and existing problems were summarized. Results MSCs can participate in all aspects of chronic wound healing to promote wound healing, and has shown broad application prospects in clinical trials. MSCs commonly used in clinical research include bone marrow-derived MSCs, adipose-derived tissue MSCs, and umbilical cord-derived MSCs. Conclusion MSCs treatment is a promising strategy for the chronic wounds, but there are still many problems in its widespread clinical application that require further research.
出处 《中国修复重建外科杂志》 CAS CSCD 北大核心 2021年第4期496-501,共6页 Chinese Journal of Reparative and Reconstructive Surgery
基金 国家自然科学基金资助项目(81871563、81372065)。
