摘要 目的观察氟比洛芬酯复合舒芬太尼用于宫颈癌根治术后镇痛的临床效果。方法选择2018年1月-2019年5月昆明医科大学第一附属医院收治的宫颈癌根治术患者80例,采用随机数字表法分为试验组和对照组各40例。试验组术后采用氟比洛芬酯复合舒芬太尼2μg/kg镇痛,对照组采用舒芬太尼4μg/kg镇痛。比较2组术后6 h、12 h、24 h和48 h疼痛视觉模拟评分法(VAS)评分,术前30 min、术后24 h和术后72 h白细胞介素-6 (IL-6)及肿瘤坏死因子-α(TNF-α)水平。结果 2组术后6 h、12 h、24 h、72 h疼痛VAS评分比较差异均无统计学意义(P>0.05)。术后1 d、3 d,2组IL-6及TNF-α水平均高于术前30 min,但试验组低于对照组(P <0.01)。结论氟比洛芬酯复合舒芬太尼用于宫颈癌根治术后镇痛可有效缓解患者的疼痛,降低炎性因子水平,且能有效减少舒芬太尼用量,临床应用价值较高。 Objective To analyze the clinical effect of flurbiprofen ester and sufentanil on postoperative analgesia of radical resection of cervical cancer. Methods Selected 80 patients undergoing radical cervical cancer surgery admitted to the First Affiliated Hospital of Kunming Medical University from January 2018 to May 2019,using random number table method,they were divided into test group and control group,each of 40 cases. The test group was treated with flurbiprofen axetil combined with sufentanil 2 μg/kg for analgesia,and the control group was treated with sufentanil 4 μg/kg for analgesia.Compared the visual analogue scale( VAS) scores of pain in the two groups at 6 h,12 h,24 h and 48 h after surgery. The levels of interleukin-6( IL-6) and tumor necrosis factor-α( TNF-α) were detected 30 minutes before operation,24 hours after operation,and 72 hours after operation in the two groups. Results There was no significant difference in pain VAS scores between the two groups at 6 h,12 h,24 h,and 72 h after surgery( P > 0. 05). At 1 and 3 days after operation,the levels of IL-6 and TNF-α in the two groups were higher than 30 min before surgery,but the test group was lower than the control group( P <0. 01). Conclusion The application of flurbiprofen ester combined with sufentanil in postoperative analgesia of cervical cancer can effectively alleviate the pain of patients,reduce the level of inflammatory factors,and effectively reduce the dosage of sufentanil,which has a high clinical value.
机构地区 昆明医科大学第一附属医院麻醉科
出处 《临床合理用药杂志》 2021年第11期31-32,35,共3页 Chinese Journal of Clinical Rational Drug Use
关键词 氟比洛芬酯 舒芬太尼 宫颈癌根治术 术后镇痛 Flurbiprofen axetil Sufentanil Radical resection of cervical cancer Postoperative analgesia
分类号 R61 [医药卫生—外科学]
