摘要 目的观察阿昔洛韦联合高压氧治疗小儿急性病毒性脑炎的临床效果。方法选取2015年5月-2018年8月宜宾市第一人民医院儿科收治的急性病毒性脑炎患儿96例为研究对象,采取随机数字表法分为观察组和对照组,每组48例。2组均予以对症支持治疗,在此基础上对照组给予阿昔洛韦抗病毒治疗,观察组在对照组基础上加用高压氧治疗,比较2组治疗效果、临床症状改善时间。结果治疗后,观察组总有效率为87.50%,高于对照组的68.75%(χ2=4.937,P=0.026);治疗后,观察组退热、意识恢复、神经反射恢复、呕吐消失及头痛消失时间均短于对照组(P <0.01)。结论阿昔洛韦联合高压氧治疗小儿急性病毒性脑炎效果较好,可有效缓解患儿症状,促进其神经细胞恢复,值得临床推广应用。 Objective To observe the clinical effect of acyclovir combined with hyperbaric oxygen in the treatment of acute viral encephalitis in children. Methods 96 children with acute viral encephalitis admitted to department of pediatrics of the First People’s Hospital of Yibin from May 2015 to August 2018 were selected as the research objects and randomly divided into observation group and control group with 48 cases in each group. Both groups were given symptomatic and supportive treatment. On this basis,the control group was treated with acyclovir and the observation group was treated with hyperbaric oxygen on the basis of the control group. The total effective rate was compared between the two groups. The antipyretic time,consciousness recovery time,nerve reflex recovery time,vomiting disappearance time and headache disappearance time were compared between the two groups. Results The time of fever abatement,the total effective rate of the observation group was87. 50%,which was higher than 68. 75% of the control group( χ2= 4. 937,P = 0. 026);the antipyretic time,consciousness recovery time,nerve reflex recovery time,vomiting disappearance time and headache disappearance time were shorter than those in the control group( P < 0. 01). Conclusion Acyclovir combined with hyperbaric oxygen can effectively alleviate symptoms and promote the recovery of nerve cells in children with acute viral encephalitis. It is worthy of clinical application.
机构地区 四川省宜宾市第一人民医院儿科
出处 《临床合理用药杂志》 2021年第11期36-37,41,共3页 Chinese Journal of Clinical Rational Drug Use
关键词 急性病毒性脑炎 小儿 阿昔洛韦 高压氧治疗 临床效果 Acute viral encephalitis Children Acyclovir Hyperbaric oxygen Clinical effect
分类号 R72 [医药卫生—儿科]
